Pore Characterization and Event Detection in Solid-State Nanopores

Nanopores are used for DNA sensing. Solid-state nanopores, which are milled through a silicon-based substrate, lack the atomic-level gemoetric precision of biological proteinmediated pores. However, they show great promise due to their greater stability and potential for modification. We developed tools to characterize solid-state nanopores by using their resistance to infer a functional diameter estimate, and developed a rudimentary protocol for DNA translocation event detection which is robust to signal degradation.